tPA Dosing (Alteplase)

Health

Tissue plasminogen activator (tPA/Alteplase) dosing for acute ischemic stroke. FDA-approved thrombolytic.

Formula

Stroke: 0.9 mg/kg (0.09 IV bolus, 0.81 infusion); AMI/PE: fixed dosing

70kg patient, acute stroke

Inputs
  • Patient Weight (kg): 70
  • Indication: stroke

63mg total: 6.3mg IV push, 56.7mg infusion

Frequently asked questions

Contraindications?
Recent surgery, active bleeding, severe hypertension. Requires urgent specialist evaluation.