PSA Density Calculator

Health

Calculate PSA density: PSA level divided by prostate volume. Used in prostate cancer screening to distinguish normal PSA elevation (large prostate) from cancer risk. PSA density > 0.15 ng/mL/cc may indicate higher cancer risk.

Formula

PSA Density = PSA Level (ng/mL) ÷ Prostate Volume (cc)
  • PSA Density helps distinguish PSA elevation from BPH (benign prostatic hyperplasia) vs cancer
  • Lower PSA density (< 0.15) suggests benign enlargement
  • Higher PSA density (> 0.25) may indicate increased cancer risk
  • Prostate volume measured by ultrasound (transrectal)
  • Used alongside PSA level and DRE in cancer screening decisions

Example

Inputs
  • PSA Level (ng/mL): 5
  • Prostate Volume (cc): 30

PSA 5 ng/mL, prostate 30 cc: PSA Density = 5 ÷ 30 = 0.17 ng/mL/cc (intermediate risk).

Frequently asked questions

What's a normal PSA density?
< 0.15 ng/mL/cc is generally considered lower risk. Higher values warrant further evaluation.
When is this calculated?
Used during prostate cancer screening when PSA is elevated or prostate is enlarged on DRE.